Bartosz Trzaskowski
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Structural and Mechanistic Basis of Selective Proteolysis by Zr-Based Metal–Organic Frameworks Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Zirconium-based metal–organic frameworks (MOFs) have emerged as promising alternatives to proteolytic enzymes, offering tunable platforms for selective protein cleavage with potential applications in proteomics, protein engineering, and therapeutic development. However, the limited mechanistic understanding of MOF–protein interactions and the molecular origins of cleavage specificity hinder their broader application as nanozymes.
Mechanistic Study of Silylacetylene Hydroboration Catalyzed by a Cobalt PN5P Pincer Complex: Catalytic Cycles Altering the Reaction Efficiency
Introduction Click to copy section linkSection link copied! Hydroboration plays a crucial role in modern organic synthesis, allowing the preparation of an interesting group of organoboron compounds with a wide range of potential applications. (1−3) Although for some highly reactive boranes (B2H6, BH3-THF) this reaction can proceed catalyst-free, in laboratory practice it is much more common to use significantly stable dioxaborolanes.
Mechanistic Study of Silylacetylene Hydroboration Catalyzed by a Cobalt PN5P Pincer Complex: Catalytic Cycles Altering the Reaction Efficiency
Introduction Click to copy section linkSection link copied! Hydroboration plays a crucial role in modern organic synthesis, allowing the preparation of an interesting group of organoboron compounds with a wide range of potential applications. (1−3) Although for some highly reactive boranes (B2H6, BH3-THF) this reaction can proceed catalyst-free, in laboratory practice it is much more common to use significantly stable dioxaborolanes.
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