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Baruch Rael Cahn on Muck Rack

Baruch Rael Cahn

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Brain-targeted epigenetic effects of two emerging psychoplastogens: ketamine & MDMA

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By Moira G. Semple, Sarah E. Mennenga, Ryan Smith, Varun B. Dwaraka, David Rabin, Berra Yazar-Klosinski, Candace Lewis, Baruch Rael Cahn, Joseph Tafur
| Nature Verified
Abstract Psychoplastogen compounds such as ketamine and MDMA have shown therapeutic promise for mood and trauma-related disorders, yet the molecular mechanisms underlying their effects remain poorly understood. Here, we applied a Brain-Epigenome-Wide Association Study (BEWAS) targeting brain-relevant genes to examine DNA methylation changes following treatment. Pre- and post-treatment blood (ketamine, N = 20) and saliva (MDMA, N = 16) samples were collected from clinical trial participants.
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