Batavia Biosciences B.V

AAA abdominal aortic aneurysm AAV adeno-associated virus AD aortic dissection Ad-5 adenovirus serotype 5 ASO antisense oligonucleotide CABG coronary artery bypass graft CHD coronary heart disease circRNA circular RNA CVD cardiovascular diseases ECM extra-cellular matrix ESC embryonic stem cell IA intracranial aneurysm LNA locked nucleic acid lncRNA long non-coding RNA miRNA microRNA ncRNA non-coding RNA PAH pulmonary arterial hypertension PAMAM polyamidoamine PASMC pulmonary arterial smooth...

Abstract Despite the development of novel pharmacological treatments, cardiovascular disease morbidity and mortality remain high indicating an unmet clinical need. Viral gene therapy enables targeted delivery of therapeutic transgenes and represents an attractive platform for tackling acquired and inherited cardiovascular diseases in the future. Current cardiovascular gene therapy trials in humans mainly focus on improving cardiac angiogenesis and function.