Baubek Spanov on Muck Rack

Baubek Spanov

As seen in: Drug Metabolism and Disposition (ASPET)
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Articles

Biotransformation of Trastuzumab and Pertuzumab in Breast Cancer Patients Assessed by Affinity Enrichment and Ion-Exchange Chromatography

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By Oladapo Olaleye, Baubek Spanov, Peter Bults, Natalia Govorukhina
| Drug Metabolism and Disposition (ASPET)
Introduction Bioanalysis is an important aspect of drug discovery and development, involving the identification and quantification of a drug and its metabolites in biologic fluids such as blood, urine, or tissue extracts (Pandey et al., 2010). Therapeutic protein (TP) drugs are heterogeneous and exist as ensembles of proteoforms due to their expression in cells as well as due to modifications occurring during production and storage (Creamer et al., 2014).
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