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Indoxil sulfato induce senescencia y liberación de microvesículas en células endoteliales que promueven la calcificación vascular
Ayuda Buscar en la ayuda Buscar en la ayuda Indoxil sulfato induce senescencia y liberación de microvesículas en células endoteliales que promueven la calcificación vascular Escobar Doncel, Beatriz [1] ; Bodega Magro, Guillermo [1] ; Carracedo Añón, Julia María [2] ; Ramírez, Rafael [1] ; Alique Aguilar, Matilde [1] [1] Universidad de Alcalá Alcalá de Henares, España [2] Universidad Complutense Localización: Dianas: revista de dianas terapéuticas, ISSN-e 1886-8746, Vol. 9, Nº.
Análogos sintéticos de ANXA1 como tratamiento para la fibrosis quística.
Ayuda Buscar en la ayuda Buscar en la ayuda Análogos sintéticos de ANXA1 como tratamiento para la fibrosis quística. Autores: Beatriz Escobar Doncel, Susana Mendoza Tamajón, Miriam Morales Gallego, Rocío Ruiz Jiménez Localización: Dianas: revista de dianas terapéuticas, ISSN-e 1886-8746, Vol. 10, Nº.
A fluorescent folding reporter uncovers myosin misfolding as a driver of Hypertrophic Cardiomyopathy
Abstract Hypertrophic cardiomyopathy (HCM) is a fatal genetic disorder causing the thickening of ventricular walls in the heart muscle. While certain mutations in cardiac myosin deregulate ATPase activity, the pathology mechanism of most HCM mutations is not known. Here, by designing a fluorescent reporter to monitor myosin folding in cells, we uncovered a distinct class of HCM mutations that cause graded defects in myosin maturation. Using C.
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