Beatriz Sanz Bernardo on Muck Rack

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Control of the induction of type I interferon by Peste des petits ruminants virus

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By Michael Baron, Beatriz Sanz Bernardo, Stephen Goodbourn
| PLOS
Peste des petits ruminants virus (PPRV) is a morbillivirus that produces clinical disease in goats and sheep. We have studied the induction of interferon-? (IFN-?) following infection of cultured cells with wild-type and vaccine strains of PPRV, and the effects of such infection with PPRV on the induction of IFN-? through both MDA-5 and RIG-I mediated pathways. Using both reporter assays and direct measurement of IFN-? mRNA, we have found that PPRV infection induces IFN-?
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