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Beichen Xie

As seen in: Science Magazine, BioRxiv
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Articles

Somatostatin triggers local cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function

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By Ceren Incedal Nilsson, Ozge Dumral, Gonzalo Sanchez Verified, Gonzalo Sánchez Verified, Beichen Xie
| tu-dresden.de
Abstract Externe IDs PubMedCentral PMC11914567 Schlagworte Animals, Humans, Mice, Calcium Signaling, Cilia/metabolism, Cyclic AMP/metabolism, Diabetes Mellitus, Type 2/metabolism, Insulin-Secreting Cells/metabolism, Receptors, Somatostatin/metabolism, Somatostatin/chemistry, Somatostatin-Secreting Cells/metabolism, Zinc Finger Protein Gli2/metabolism, Calcium/metabolism, Male, Female, Middle Aged, Aged, Aged, 80 and over
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δ-α cell-to-cell interactions modulate pancreatic islet Ca2+ oscillation modes

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By Chao Tang, Huixia Ren, Yanjun Li, Beichen Xie
| BioRxiv
Abstract Glucose-induced pancreatic islet hormone release is tightly coupled with oscillations in cytoplasmic free Ca2+ concentration of islet cells, which is regulated by a complex interplay between intercellular and intracellular signaling. Delta cells, which entangle with alpha cells located at the islet periphery, are known to be important paracrine regulators. However, the role of delta cells in regulating Ca2+ oscillation pattern remains unclear.
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Locally released somatostatin triggers cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function

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By Ozge Dumral, Gonzalo Sanchez Verified, Gonzalo Sánchez Verified, Beichen Xie, Ceren Incedal Nilsson
| BioRxiv
Abstract Somatostatin is produced and released from δ-cells within pancreatic islets of Langerhans and constitutes one of the most important negative regulators of islet hormone secretion. Somatostatin receptors (SSTR) are abundantly expressed in the islet cells and coupled to Gαi and lowering of intracellular cAMP. We find that both SSTR3 and SSTR5 localize to primary cilia of β-cells, and that activation of these receptors lowers the ciliary cAMP concentration.
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