Ben Barron-Millar

INTRODUCTION Type 1 interferons (IFN-Is) have pleiotropic effects on the immune system and prime cellular responses to effectively clear, typically viral, infection.1 In this context, widespread cellular activation is desirable, but in the absence of infection, IFN-I–associated increased cellular priming or activation can be inappropriate.2 Excess IFN-α can promote a breach of tolerance in autoantibody producing B cells as well as facilitate more effective presentation of antigen, potentially...

FULL LENGTH Nicola J Maney, orcid.org/0000-0002-6079-2914 Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK Search for more papers by this author Henrique De Paula Lemos, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK These authors contributed equally.