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Ben Caswall

As seen in: Nature
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Articles by Ben Caswall

FKS1/2 -variant independent mechanisms underlying the emergence of resistance in echinocandin-refractory Candida auris infections

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By Hugh Gifford, Arnab Pradhan, Sarah Murphy, Ian Leaves, Matt Edmondson, Tanmoy Chakraborty Verified, Duncan Wilson Verified, Surabhi K. Taori, Neil Gow, Rhys A. Farrer, Alistair Brown, Tihana Bicanic, Ben Caswall
| Nature Verified
Abstract The emerging fungus Candida auris is a drug resistant global public health threat and WHO critical priority pathogen. Recommended first-line invasive candidiasis treatment is echinocandin monotherapy, but C. auris can develop on-treatment resistance via FKS1/2 gene mutations and additional, previously unexplained mechanisms. To better understand echinocandin failure in C. auris, we sequenced the genomes of echinocandin refractory FKS1/2 wild-type C.
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