Duncan Wilson on Muck Rack

Duncan Wilson

Verified
Auckland
As seen in: Illumination, Medium, Nature, Wiley Online Library, Yahoo News Australia, The London Standard, MDPI, Yahoo Sports Canada, Science Magazine, Yahoo Style Canada and
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Articles

Defining Utility as a Measure of Preference Under Uncertainty in Phase I–II Oncology Dose Finding Trials

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By Andrew Hall, Duncan Wilson Verified, Stuart Barber
| Wiley Online Library Verified
1 Introduction The dose selection paradigm in oncology has been shaped historically by the prognosis of diagnosis, the lack of effective treatments, and the properties of cytotoxic treatments coming through development [1].
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Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish (Aphanius dispar) infection - Communications Biology

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By Hugh Gifford, Jack Gregory, Alexandra Brand, Duncan Wilson Verified, Johanna Rhodes
| Nature Verified
Abstract Candida auris is a critical priority fungal pathogen (World Health Organization). Clinical management is challenging, with high associated mortality, rapidly increasing antifungal resistance, and frequent nosocomial outbreaks. A critical bottleneck in understanding virulence is the lack of gene expression profiling models during infection. We developed a fish embryo yolk-sac microinjection model using Aphanius dispar (Arabian killifish; AK) at human body temperature.
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Structural insights into mechanisms of zinc scavenging by the Candida albicans zincophore Pra1 - Nature Communications

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By Rajika L. Perera, Duncan Wilson Verified
| Nature Verified
Abstract Candida albicans causes over 400,000 life-threatening, and an additional half a billion of mucosal infections annually. In response to infection, the host limits essential micronutrient availability, including zinc, to restrict growth of the invading pathogen. As assimilation of zinc is essential for C. albicans pathogenicity, limitation induces secretion of the zincophore protein Pra1 to scavenge zinc from the host.
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