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Benfan Lin on Muck Rack

Benfan Lin

As seen in: Frontiers, Frontiers in Immunology
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Articles

Post-transcriptional regulation via alternative polyadenylation and piRNA shapes macrophage responses in psoriasis

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By Benfan Lin, Xiwang Du, Zongshan Wang, Yan Zhao, Yue Feng, Liqian Liu, Leihong Lu
| Frontiers in Immunology
Abstract Background: Post-transcriptional regulatory mechanisms underlying autoimmune diseases remain poorly understood. Here, we employed integrated multi-omics approaches to systematically dissect the role of alternative polyadenylation (APA) and piRNA-mediated regulation in psoriasis pathogenesis. Methods: We performed transcriptome-wide association studies (TWAS) combined with Mendelian randomization to identify causal susceptibility genes.
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Local Promoter Methylation Disorder algorithm reveals bidirectional epigenetic disruption in DNMT3A-mutated AML and predicts azacitidine treatment response

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By Xin L. Liu, Miaomiao Cui, Shuqiang Cheng, Benfan Lin
| Frontiers
Abstract Background: DNMT3A mutations occur in 20-25% of acute myeloid leukemia (AML) cases and are associated with poor prognosis, yet the epigenetic mechanisms underlying treatment response remain poorly understood. Traditional methylation analyses focus on mean levels, overlooking the heterogeneity that may be central to therapeutic vulnerability.
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