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Benjamin B. Bartelle on Muck Rack

Benjamin B. Bartelle

Boston
As seen in: Nature, PLOS ONE, Journal of Chemical & Engineering Data, BioRxiv
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Articles

Digit regeneration in mice is stimulated by sequential treatment with FGF2 and BMP2

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By Ling Yu, Mingquan Yan, Osama Qureshi, Benjamin B. Bartelle, Daniel Hurtado, James J. Cai, Lindsay Dawson, Regina Brunauer, Larry J Suva, Connor Dolan, Ken Muneoka, Katherine Zimmel Scaturro, Yu-Lieh Lin, C. Addison Smith, Manjong Han
| Nature Verified
Abstract Epimorphic regeneration in mice is stimulated at a non-regenerative digit amputation by sequential treatment with FGF2 and BMP2 (FGF2→BMP2). FGF2 stimulates digit amputation wound cells to form a blastema and BMP2 induces blastema differentiation to regenerate the amputated distal phalangeal element, albeit imperfectly.
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Classifying cell cycle states and a quiescent-like G0 state using single-cell transcriptomics

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By Samantha O'Connor, Leonor Garcia Verified, Anoop P. Patel, Benjamin B. Bartelle
| BioRxiv
Abstract Single-cell transcriptomics has unveiled a vast landscape of cellular heterogeneity in which the cell cycle is a significant component. We trained a high-resolution cell cycle classifier (ccAFv2) using single cell RNA-seq (scRNA-seq) characterized human neural stem cells. The ccAFv2 classifies six cell cycle states (G1, Late G1, S, S/G2, G2/M, and M/Early G1) and a quiescent-like G0 state (qG0), and it incorporates a tunable parameter to filter out less certain classifications.
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Ts-Biotag, a multimodal reporter of Tie2 expression, labels microglia in a model of neuro injury.

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By Benjamin B. Bartelle, Zeinab Tashi, Jennifer Brodsky, Kezia Sharon Christopher
| BioRxiv
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