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Abstract Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by providing high-resolution insights into biological macromolecules. Here, we present sub-3 Å resolution structures determined using the 100 keV Tundra cryogenic transmission electron microscope (cryo-TEM), equipped with the newly developed Falcon C direct electron detector (DED).
Abstract Transthyretin (TTR) is a natively tetrameric thyroxine transporter found in blood and cerebrospinal fluid whose misfolding and aggregation causes transthyretin amyloidosis. A rational drug design campaign identified the small molecule Tafamidis (Vyndamax) as an effective stabilizer of the native TTR fold, and this aggregation inhibitor is regulatory agency-approved for the treatment of TTR amyloidosis.
An enumerative algorithm for de novo design of proteins with diverse pocket structures Benjamin Basanta, Matthew J. Bick, Asim K. Bera, Christoffer Norn, Cameron M. Chow, Lauren P. Carter, Inna Goreshnik, Frank Dimaio, David Baker Proceedings of the National Academy of Sciences Aug 2020, 202005412; DOI: 10.1073/pnas.2005412117
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