Benjamin Geier

Abstract UBE3A encodes a HECT-type E3 ubiquitin ligase essential for neurodevelopment. Loss of maternal UBE3A causes Angelman syndrome (AS), while maternal duplications of 15q11.2–q13.1 (including UBE3A) lead to Dup15q syndrome, both characterized by severe neurological impairment and epilepsy. Despite its importance, few disease-relevant substrates have been identified due to the transient and low-stoichiometric nature of E3–substrate interactions.

1. Big week for American health care: The public -- and lawmakers -- will learn the cost of Senate Republicans' attempt to repeal and replace Obamacare. The Congressional Budget Office is expected to release its score of the Senate health care bill. The nonpartisan office will also estimate how many people would be covered under the bill.

As Twitter’s board searches for someone to lead the company in the wake of Dick Costolo’s departure, the board has a message for co-founder and interim CEO Jack Dorsey — give up your other company or don’t expect to be asked to stay.