Benjamin Geller
As seen in:
Nature,
Sportskeeda,
BioRxiv,
Cell Press,
Physical Review B,
Bloody Elbow,
Law360,
Law360 UK
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Articles by Benjamin Geller
Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression
Abstract The short-chain fatty acids (SCFA) propionate and butyrate have beneficial health effects, are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks.
Short-chain fatty acids propionate and butyrate control growth and differentiation linked to cellular metabolism
Abstract The short-chain fatty acids (SCFA) propionate and butyrate are produced in large amounts by microbial metabolism and have been identified as unique acyl lysine histone marks. In order to better understand the function of these modifications we used ChIP-Seq to map the genome-wide location of four short-chain acyl histone marks H3K18pr/bu and H4K12pr/bu in treated and untreated colorectal cancer (CRC) and normal cells, as well as in mouse intestines in vivo.
Ga. Appeal Shows Benefits Of Questioning Jury Instructions
ADVERTISEMENT Don't want ads? Subscribe or login now. By Brett Tarver, Frederick King and Benjamin Geller (November 21, 2023, 10:27 AM EST) -- As any seasoned trial attorney will tell you, one key event during a jury trial is the reading of the jury instructions to the jury. During the reading of the instructions, the jury hears at length from the one impartial authority in the courtroom: the judge....
A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA - Nature Communications
Abstract RNA polymerase III (Pol III) includes two alternate isoforms, defined by mutually exclusive incorporation of subunit POLR3G (RPC7α) or POLR3GL (RPC7β), in mammals. The contributions of POLR3G and POLR3GL to transcription potential has remained poorly defined. Here, we discover that loss of subunit POLR3G is accompanied by a restricted repertoire of genes transcribed by Pol III. Particularly sensitive is snaR-A, a small noncoding RNA implicated in cancer proliferation and metastasis.
Assessing the impact of introductory physics for the life sciences on students' ability to build complex models
Abstract A central goal of introductory physics for the life sciences (IPLS) is to prepare students to use physics to model and analyze biological situations, a skill of increasing importance for their future studies and careers. Here we report our findings on life science students’ ability to carry out a sophisticated biological modeling task at the end of first-semester introductory physics.
Chromatin Remodeling in Response to BRCA2-Crisis
Highlights • Transient BRCA2 loss (“BRCA2-crisis”) in mammary cells enables EGF-independent growth • NF-κB activation promotes H4 acetylation after BRCA2-crisis • BRCA2-crisis increases tumorigenic potential in vivo • BRCA2-crisis and BRCA2+/− carriers share common gene expression and chromatin states Summary Individuals with a single functional copy of the BRCA2 tumor suppressor have elevated risks for breast, ovarian, and other solid tumor malignancies.
HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding
Highlights • HAT1 is an EGF-stimulated acetyltransferase required for EGF-dependent growth • HAT1 holoenzyme specifically binds to histone H4 promoters • Histone H4 promoters contain an acetate-sensitive genomic element • HAT1 expression is associated with poor cancer outcomes in humans and mice Summary The energetic costs of duplicating chromatin are large and therefore likely depend on nutrient sensing checkpoints and metabolic inputs.
Opinion: Faking Injuries Needs to Stop
Football is a sport in which players are bound to be injured sometime in their career, most of the time earlier than later. Even some of the best players get injured frequently, such as JJ Watt who plays for the Huston Texans or Kenan Allen who plays for the Los Angeles Chargers. When these players get hurt the natural reaction is for the stadium to get quiet, and then for everyone to clap in respect of the player, and hope he is okay.
3 Reasons Dustin Poirier Deserves a UFC Lightweight Title Shot
The UFC Fight Night in Calgary ended up being one of the best fight nights of the year. Eddie Alvarez fought Dustin Poirier in the main event, and it did not disappoint. Both of these fighters are fan favorites to watch, because of there action-packed and offensive fighting styles. The Alvarez versus Poirier 2 fight ended up being one of the most anticipated matches, as a result of the controversy in their first fight.
Preview of Miocic vs Ngannou
Two weeks ago at UFC 218, one of the most shocking fights was Francis Ngannou versus Alistair Overeem. On face it would be assumed that Overeem would be the favorite being the Strikeforce Heavyweight Champion, DREAM Interim Heavyweight Champion, K-1 World Grand Prix Champion, and the number one UFC contender in the heavyweight division. Even with all the accolades Overeem has, Francis Ngannou the number four contender knocked him out with a brutal uppercut to the head.
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