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Abstract Animal pigment patterns are excellent models to elucidate mechanisms of biological organization. Although theoretical simulations, such as Turing reaction–diffusion systems, recapitulate many animal patterns, they are insufficient to account for those showing a high degree of spatial organization and reproducibility. Here, we study the coat of the African striped mouse (Rhabdomys pumilio) to uncover how periodic stripes form.
Highlights • An in vivo rAAV-based genome-editing method (TIGER) was developed in R. pumilio • TIGER generates knockout and knockin striped mouse lines with high efficiency • A double-cleaving repair rAAV template increases knockin rate and transmission • An oversized double-cleaving rAAV template leads to an insertion of 3.8 kb Summary Rodents are taxonomically diverse and have evolved a variety of traits.
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Report View ORCID ProfileKarin R. L. van der Burg1,*, View ORCID ProfileJames J. Lewis1,2, Benjamin J. Brack1, View ORCID ProfileRichard A. Fandino1, View ORCID ProfileAnyi Mazo-Vargas1, View ORCID ProfileRobert D. Reed1,* 1Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, USA. 2Baker Institute for Animal Health, Cornell University, Ithaca, NY, USA. ↵*Corresponding author.
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