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4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

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By benjamin philipson, Roddy S. O’Connor, Michael May, Carl June
| Science Magazine Verified
Ensuring the persistence of CAR T cells Optimal antitumor responses in patients treated with chimeric antigen receptor (CAR) T cells correlates with the persistence of these cells after treatment. Confirming patient data, Philipson et al. found that 4-1BB–expressing CAR T cells survived longer and increased in number to a greater extent ex vivo compared to CD28-expressing CAR T cells.
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