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Abstract Autograft repairs remain inferior to primary neurorrhaphy, largely due to axonal regeneration across two coaptation sites. PEG–mediated neurorrhaphy has been shown to enhance recovery following peripheral nerve injury by mitigating Wallerian degeneration. Whether PEG can overcome these limitations in human autografts remains unclear. We therefore compared sensory recovery following PEG-mediated primary versus PEG-mediated autograft neurorrhaphy.
In modern surgical practice, targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI) offer amputees promising options for painful neuroma management, with the potential to significantly reduce pain and enhance prosthetic control. Despite these advancements, a lack of consensus on the standard of care persists, largely due to methodological inconsistencies in the current literature.
Aims Functional hydrogel dressings offer a promising therapeutic approach, and optimizing their formulations is crucial for improving diabetic foot ulcers (DFUs) outcomes. This study explores the comparative efficacy of different functional hydrogel dressings in DFUs treatment. Materials and Methods We conducted a systematic review and Bayesian network meta-analysis of randomized controlled trials evaluating functional hydrogel dressings for DFUs treatment.
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