Benkui Zou on Muck Rack

Benkui Zou

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CircIQGAP1-CARM1 axis promotes renal cell carcinoma progression through glycolytic reprogramming

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By Ruyue Jia, Yiran Liang, Tao Chen, Xiangzhi Li, Chao Zhang, Fajun Pei, Xuehua Zhu, Benkui Zou, Qingkun Chen, Jiasheng Bian, Renbo Guo
| Nature Verified
Abstract Renal cell carcinoma (RCC) relies heavily on aerobic glycolysis for rapid proliferation and metastasis; however, the role of circular RNAs (circRNAs) in this process remains unclear. This study identified circIQGAP1 as a key regulator; its expression was upregulated under glucose deficiency, with U2AF2 promoting its biosynthesis. Functional assays showed that circIQGAP1 enhances RCC cell proliferation, motility, invasion, and glycolytic flux.
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