Bennett Tochukwu Amaechi

Abstract This in vitro study used a pH cycling model to compare the caries remineralizing efficacy of toothpaste formulations containing calcium hypophosphite (CaP), hydroxyapatite (HAP), or sodium fluoride (NaF). Bovine enamel blocks with plaque-induced initial caries lesions were randomized (n = 30/group) to toothpaste formulations containing 1% CaP, 20% HAP, 1% CaP+20% HAP, or 1450 ppm fluoride provided as NaF.

Back to Journals » Clinical, Cosmetic and Investigational Dentistry » Volume 18 Authors Amaechi BT , Abdollahi S, Vohra R, Omosebi TO , Vazir R, Nguyen D, Ussery KA, Obiefuna AC Received 7 January 2026 Accepted for publication 19 March 2026 Published 25 March 2026 Volume 2026:18 Pages 1—14 DOI https://doi.org/10.2147/CCIDE.S590870 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Christopher E.

Introduction Caries remains highly prevalent worldwide.1 The primary cause of caries is dental plaque, where bacteria metabolize sugars into acids that demineralize the mineral phase of the tooth structure.