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Bennett True

As seen in: BioRxiv
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Articles

Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP

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By Alexandria Leveille, Hawley Brown, Thomas Schwarzrock, Bennett True
| BioRxiv
Abstract Herein we report the first structure-activity studies of compound GW5074 which has demonstrated binding affinity to autophagy-related proteins LC3B and GABARAP. The literature has conflicting information on the binding affinities of this compound to LC3B and GABARAP, and there is some debate regarding its use as a component of autophagy-targeting chimeras (AUTACs) or autophagosome-tethering chimeras (ATTECs).
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