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Benoit Darlot

As seen in: Royal Society of Chemistry, The Journal of Biological Chemistry
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Articles by Benoit Darlot

Fragment expansion with NUDELs - poised DNA-encoded libraries

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By Bedson Building, Benoit Darlot, Jack Davison, Mathew Martin
| Royal Society of Chemistry Verified
Fragment expansion with NUDELs – poised DNA-encoded libraries† Optimisation of the affinity of lead compounds is a critical challenge in the identification of drug candidates and chemical probes and is a process that takes many years. Fragment-based drug discovery has become established as one of the methods of choice for drug discovery starting with small, low affinity compounds. Due to their low affinity, the evolution of fragments to desirable levels of affinity is often a key challenge.
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Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction

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By 'S Choice, Benoit Darlot, of Oxford
| The Journal of Biological Chemistry Verified
Author contributions—B. D., J. R. O. E., L. G.-A., G. K. Y., A. K., and S. B. conceptualization; B. D., J. R. O. E., L. G.-A., G. K. Y., K. K., C. V. R., and A. K. data curation; B. D., J. R. O. E., L. G.-A., G. K. Y., G. D., C. V. R., A. K., and S. B. formal analysis; B. D., J. R. O. E., L. G.-A., G. K. Y., K. K., G. D., C. V. R., A. K., and S. B. supervision; B. D., L. G.-A., A. K., and S. B. funding acquisition; B. D., J. R. O. E., L. G.-A., G. K. Y., K. K., G. D., C. V. R., A. K., and S. B. investigation; B. D., J. R. O. E., L. G.-A., G. K. Y., K. K., G. D., C. V.
Open in Who Shared View Duplicates (4) Issue with article?

Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction

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By James Eaton, Benoit Darlot, Lucia Geis-Asteggiante, Gopala K. Yakala
| The Journal of Biological Chemistry Verified
Author contributions: B.D., J.R.E., L.G.-A., G.K.Y., A.K., and S.B. conceptualization; B.D., J.R.E., L.G.-A., G.K.Y., K.K., C.V.R., and A.K. data curation; B.D., J.R.E., L.G.-A., G.K.Y., G.D., C.V.R., A.K., and S.B. formal analysis; B.D., J.R.E., L.G.-A., G.K.Y., K.K., G.D., C.V.R., A.K., and S.B. supervision; B.D., L.G.-A., A.K., and S.B. funding acquisition; B.D., J.R.E., L.G.-A., G.K.Y., K.K., G.D., C.V.R., A.K., and S.B. investigation; B.D., J.R.E., L.G.-A., G.K.Y., K.K., G.D., C.V.R.,...
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