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Abstract Extrachromosomal DNA (ecDNA) comprises megabase-sized circular DNA elements that frequently carry oncogene amplifications, driving aggressive tumour phenotypes, therapeutic resistance and poor clinical outcomes across many cancers1,2,3,4. Although ecDNA is thought to arise from canonical double-strand break repair, the pathways that maintain it remain unclear.
Keywords PCP single-molecule nucleosome arrays cohesin overlapping Di-nucleosome OLDN Get full text access Log in, subscribe or purchase for full access. References 1. Jiang, C. ∙ Pugh, B.F. Nucleosome positioning and gene regulation: advances through genomics Nat. Rev. Genet. 2009; 10:161-172 2. Baldi, S. ∙ Korber, P. ∙ Becker, P.B. Beads on a string-nucleosome array arrangements and folding of the chromatin fiber Nat. Struct. Mol. Biol. 2020; 27:109-118 3.
Abstract Chromatin plays a pivotal role in genome expression, maintenance, and replication. To better understand chromatin organization, we developed a novel proximity-tagging method which assigns unique DNA barcodes to molecules that associate in 3D space. Using this method,Proximity Copy Paste (PCP), we mapped the connectivity of individual nucleosomes in Saccharomyces cerevisiae.
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