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DISCUSSION To our knowledge, this is the first systematic review to examine published cases of myelosuppression in colchicine use in the context of rheumatic conditions. We identified 30 reports of 47 patients with myelosuppression. Across the 47 studies, there were 15 patients taking CYP3A4 inhibitors and 13 patients taking P-gp inhibitors, suggesting that drug interactions contributed to myelosuppression.
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Differentiation of HD and Isogenic Control hiPSCs into Forebrain Neural Cells Analysis of Differential Gene Expression in HD and Isogenic Control hiPSCs and Differentiated NPCs To identify transcriptional changes resulting from mutant HTT in our established human HD isogenic models, we performed a global differential gene expression analysis in hiPSC and NPC lines (Figure 6Figure 6A).
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