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Bersabeh Tigabu on Muck Rack

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Phosphorylated VP30 of Marburg Virus Is a Repressor of Transcription

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By Palaniappan Ramanathan, Bersabeh Tigabu, Andrey Ivanov, Xionghao Lin
| asm.org
ABSTRACTThe filoviruses Marburg virus (MARV) and Ebola virus (EBOV) cause hemorrhagic fever in humans and nonhuman primates, with high case fatality rates. MARV VP30 is known to be phosphorylated and to interact with nucleoprotein (NP), but its role in regulation of viral transcription is disputed. Here, we analyzed phosphorylation of VP30 by mass spectrometry, which resulted in identification of multiple phosphorylated amino acids.
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