Betelehem Solomon Bera on Muck Rack

Betelehem Solomon Bera

As seen in: Wiley Online Library
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Articles

Dysregulated airway epithelial antiviral immunity in Down Syndrome impairs type III IFN response and amplifies airway inflammation during RSV infection.

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By Elizabeth Chorvinsky, Surajit Bhattacharya, Betelehem Solomon Bera, Allison Welham
| biorxiv.org
Abstract Trisomy 21 (TS21), also known as Down syndrome (DS), increases pediatric mortality risk from respiratory syncytial virus (RSV) by nine-fold, yet its underlying immunological basis remains unclear. Here, we investigated RSV-induced immunological responses in TS21 airway epithelial cells (AECs), the primary site of respiratory virus entry and host defense.
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High TSLP responses in the human infant airways are associated with pre‐activated airway epithelial IFN antiviral immunity

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By Elizabeth Chorvinsky, Surajit Bhattacharya, Allison Welham, Betelehem Solomon Bera
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT The authors have no competing interests. Supporting Information Filename Description imm13741-sup-0001-supinfo.docxWord 2007 document , 83.7 KB Data S1. Supporting Information. REFERENCES 1, . TSLP: from allergy to cancer. Nat Immunol. 2019; 20: 1603–1609. 2, . Role of thymic stromal lymphopoietin in allergy and beyond. Nat Rev Immunol. 2022; 23: 24–37. https://doi.org/10.1038/s41577-022-00735-y 3, , , , .
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