Bethany Mitchell

B-cell precursor acute lymphoblastic leukemia (B-ALL) is the commonest childhood malignancy [1]. While most newly diagnosed patients can be cured, relapse outcomes remain poor, with resistant disease common [2]. Established relapse protocols, such as ALL R3, rely on highly intensive chemotherapy to induce remission but are associated with a significant risk of treatment-related mortality (TRM) [3, 4], limiting delivery of effective therapy.

Four million dollars, and then some. That’s how much the Mercedes Marathon has raised in support for local Birmingham charities. THE STORY A daddy’s promise to his ill little boy generated the creation of this race. You get through this surgery, and I’ll run a marathon for you, Paul Sotherland had said. The proposal: a heart-pounding 26.2 mile run if his son with Down syndrome pushed through a critical open-heart surgery. His son proved his endurance, and so did Paul.