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Bhavyasree Papineni on Muck Rack

Bhavyasree Papineni

As seen in: Nature
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Articles

Disrupting Treg lineage stability elicits RORgT-mediated plasticity and enhances anti-tumor immunity

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By Courtney Swain, Dominique C. Hinshaw, Ian Miranda, Brandon Metge, Amr R. Elhamamsy, Dongquan Chen, Alyssa Lee, Hua Guo, Bhavyasree Papineni, Jeffrey Rathmell, Selvarangan Ponnazhagan, Robert S. Welner, Rajeev Samant, Lalita A. Shevde, Li’an Williams
| Nature Verified
Abstract The imbalance of pro-inflammatory and immunosuppressive constituents in the tumor microenvironment (TME) significantly dictates cancer progression, immune invasion, and treatment response. Immunosuppressive regulatory T cells (Tregs) are associated with decreased disease-free survival due to their ability to suppress anti-tumor immunity. Notably, in response to environmental cues, Tregs display functional and phenotypic plasticity with inflammatory helper T cell subsets.
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TRMT112 drives a tumor growth and metastasis-promoting program in triple-negative breast cancer - Cell Death & Differentiation

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By Amr R. Elhamamsy, Rajeev Samant, Bhavyasree Papineni
| Nature Verified
Abstract Ribosomal RNA Modifying Proteins (RRMPs) are integral to ribosome biogenesis, executing post-transcriptional modifications that influence translation fidelity and efficiency. Dysregulation of RRMPs has been increasingly implicated in cancer progression, yet their collective role across malignancies remains largely unexplored.
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