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Promoter TERT- Related Hematopoietic Somatic Mosaicism in Patients With Telomere Biology Disorders
To the Editor, Telomere biology disorders (TBDs) are characterized by critically shortened telomere lengths (TL) with multiorgan involvement [1]. Hematologic manifestations are frequent and include cytopenias, bone marrow failure (BMF), and an increased risk of malignancy, with observed-to-expected (O:E) ratios of 49.50 and 529.70 for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), respectively [2-4].
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