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Bianca M. Berger on Muck Rack

Bianca M. Berger

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Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis - Nature Communications

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By Daniel J Ham, Timothy McGowan, Eleonora Maino, Bianca M. Berger
| Nature Verified
Abstract The oncogenic transcription factor Myc stimulates many growth processes including cell cycle progression and ribosome biogenesis. Myc expression is low in adult skeletal muscle, but is upregulated upon growth stimuli. Furthermore, muscle fiber Myc overexpression recapitulates many aspects of growth-related gene expression, leading to the hypothesis that Myc mediates pro-growth responses to anabolic stimuli, such as exercise.
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