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Bibigul Tleumagambetova on Muck Rack

Bibigul Tleumagambetova

As seen in: Frontiers, Frontiers in Immunology
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Articles

Metabolic heterogeneity at the onset of type 2 diabetes: phenotypes of insulin resistance and β-cell function in the Kazakh population

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By Bibigul Tleumagambetova, Khatimya Kudabayeva, Yerlan Bazargaliyev, Raikul Kosmuratova
| Frontiers
Abstract Background: Type 2 diabetes mellitus (T2DM) is increasingly recognized as a heterogeneous metabolic disorder characterized by varying contributions of insulin resistance and pancreatic β-cell dysfunction. However, data on early metabolic phenotypes at diagnosis remain limited in Central Asian populations.
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IL-1β/IL-1Ra ratio dysregulation in islet autoantibody–positive adult-onset diabetes

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By Khatimya Kudabayeva, Yerlan Bazargaliyev, Bibigul Tleumagambetova, Lorina Vudu
| Frontiers in Immunology
Abstract Background: The IL-1 pathway plays a central role in β-cell dysfunction; however, the relationship between IL-1β/IL-1Ra imbalance and islet autoimmunity in newly diagnosed adult-onset diabetes remains insufficiently defined. This study aimed to evaluate whether dysregulation of the IL-1β/IL-1Ra ratio differs according to islet autoantibody status. Methods: This cross-sectional study included 240 adults with newly diagnosed adult-onset diabetes recruited from primary healthcare facilities.
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