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Bichitra K. Biswal on Muck Rack

Bichitra K. Biswal

As seen in: Nature
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Articles

A programmable lipid-triggered allosteric site modulates LC3 LIR receptor binding activity

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By Deepanshi Gahlot, Jesu Castin, Shruti Mathur, Debajyoti Das, Ajit Kumar, Chandrima Gain, Mridul Sharma, Ravi Pal, Niyati Jain, Rajat Singh, Lipi Thukral, Akanksha Arun, Bichitra K. Biswal
| Nature Verified
Abstract Membrane recruitment is a fundamental regulator of protein function. However, the allosteric mechanisms by which lipid binding controls protein activity remain poorly understood. In autophagy, the ubiquitin-like protein LC3 is lipid-anchored to autophagosomes, where it is essential for receptor recruitment and vesicle formation. While LC3-receptor interactions are structurally well defined, how membrane engagement governs LC3 functional dynamics has remained enigmatic.
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