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Bing-Ying Ho

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Articles

Near-infrared-activated indocyanine green enhances cisplatin-induced c-Fos-mediated apoptosis in colorectal cancer cells

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By Bing-Ying Ho, Jong-Kai Hsiao, Chung-Hsien Chan
| Nature Verified
Abstract Colorectal cancer (CRC) treatment remains limited by chemoresistance, highlighting the need for combination strategies that enhance therapeutic responses. Indocyanine green (ICG) is a clinically approved near-infrared (NIR)-responsive agent with photothermal and photodynamic properties. Here, we investigated the effects of NIR-activated ICG combined with cisplatin (CDDP) and the associated apoptotic mechanisms in HCT116 and HT29 CRC cells.
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Human lncRNAs NEAT1 and MALAT1 regulate the tumor microenvironment in lung cancer PDX models in athymic nude mice - Scientific Reports

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By Bing-Ying Ho
| Nature Verified
Abstract We employed PDX models in athymic nude mice to generate lung cancer tumors, aiming to improve early detection and enable personalized treatments. The athymic nude mouse was utilized as the lung cancer PDX model, maintaining the histological and pathological integrity of lung cancer. This model allowed for the analysis of microenvironments through whole transcriptome sequencing to assess gene expression variations across different passages of the PDX model.
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