Bingying Du

To explore the potential clinical implications of the fibrosis panel, we examined the relationship between 10 fibrosis-related metabolites and the key clinicopathological indicators, especially the fibrosis score, in patients with MASLD. Correlation analysis showed that the bile acids GCDCA and CDCA were positively correlated with fibrosis staging, whereas GAA and indole-3-propionic acid were negatively correlated (Figure 6A), suggesting that the fibrosis panel may reflect liver fibrosis.

Abstract Vascular dementia (VaD) is the second most common cause of dementia. Few bioinformatic analysis has been done to explore its biomarkers. This study aimed to excavate potential biomarkers for VaD using bioinformatic analysis and validate them at both animal and patient levels. Based on microarray data of GSE122063, bioinformatic analysis revealed 502 DEGs in the frontal and 674 DEGs in the temporal cortex of VaD patients.

1 Introduction Neuronal ceroid lipofuscinosis (NCL), also known as Batten disease, refers to a group of neurodegenerative lysosomal storage diseases (LSDs), which is characterized by the excessive accumulation of lysosomal lipofuscin in multiple tissue [1, 2]. NCL represents a complex and diverse group of neurodegenerative disorders with pathophysiology involving multiple genes and cellular processes.