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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Numerical investigation of water-exit hydrodynamics of an axisymmetric body in waves and currents
The water exit of an axisymmetric body represents a typical unsteady multiphase flow process, in which the hydrodynamic forces become highly complex due to dynamic fluid–structure interactions. In this study, the applicability of the Volume of Fluid (VOF) multiphase model, turbulence model, cavitation model, and overset mesh technique was validated through a series of numerical simulations.
Small interfering RNA-mediated silencing of mutant NPM1 suppresses acute myeloid leukemia via reversing KAT7 and p300-mediated histone acetylation
Abstract NPM1 mutation (NPM1c)-driven acute myeloid leukemia (AML) is characterized by the sequestration of nuclear proteins and chromatin hijacking. Current treatment strategies targeting NPM1c AML are often indirect, which might lead to toxicity and resistance. In this study, we developed an allele-specific siRNA that selectively silences NPM1c while preserving the function of wild-type NPM1.
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