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Binyin Li on Muck Rack

Binyin Li

As seen in: Nature, Cell Reports Medicine, Alzheimer's & Dementia
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Articles

Advancing Alzheimer’s disease research in China: insights, innovations, and future directions from the chinese preclinical Alzheimer’s disease study (CPAS)

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By Jie Wang, Lin Huang, Binyin Li, Qihao Guo, Fang Xie
| Nature Verified
Abstract This review delves into the advancements in Alzheimer’s Disease (AD) research in China, focusing on insights, innovations, and future directions derived from the Chinese Preclinical Alzheimer’s Disease Study (CPAS). With an aging population, AD prevalence has risen, increasing societal and economic burdens. CPAS, initiated in 2019, aims to identify early Alzheimer’s pathology using plasma biomarkers and PET imaging.
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Regional juxtacortical microstructural changes and gene expression provide insights into neurodegeneration in Alzheimer’s disease

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By Junfang Zhang, Lipeng Sun, Xinyuan Yang, Lin Kang, Yingting Zheng, Qi Huang, Wei Xu, Yihui Guan, Jun Liu, Yulei Deng, Fang Xie, Xiaomeng Xu, Binyin Li
| Nature Verified
Abstract White matter microstructural changes play a crucial role in cognitive decline in aging and neurodegenerative disorders including Alzheimer’s disease (AD). However, the processes underlying white matter microstructural changes and the molecular pathways leading to these changes in AD remain largely unknown. AD involves cortical and juxtacortical microstructural changes, with free water fraction (FWF) as a potential imaging marker.
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Plasma growth-associated protein 43 correlates with synaptic loss in Alzheimer’s disease

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By Guoyu Lan, Binyin Li, Mengjie Wang, Aatmika Barve, Morvane Colin, Luc Buée, Laihong Zhang, Mingxing Jiang, Jie Yang, Anqi Li, Zhengbo He, Xin Zhou, Yalin Zhu, Yue Cai, Pan Sun, Lin Liu, Linting Chen, Lili Fang, Yiying Wang, Mingxu Li, Xuhui Chen, Dai Shi, Chenghui Ye, Xiang Fan, Qingyong Wang, Liemin Zhou, Zhen Liu, Ying Han, Lu Wang, Guanxun Cheng, Yihui Guan, Ruiqing Ni, Kevin Richetin, Fang Xie, Tengfei Guo, Jieyin Li
| Cell Reports Medicine Verified
Keywords synaptic loss blood biomarkers GAP-43 extracellular vesicles neuropathology Alzheimer’s disease Introduction Dementia is the leading cause of disability and death among older adults and currently affects over 55 million people worldwide.1 Approximately 60%–70% of dementia cases are attributed to Alzheimer’s disease (AD), marked by the deposition of extracellular amyloid-β (Aβ) plaques and intraneuronal tau tangles composed of phosphorylated tau (p-tau), and then dementia with Lewy...
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