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Binyin Li on Muck Rack

Binyin Li

As seen in: Nature, Cell Reports Medicine, Alzheimer's & Dementia
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Articles

Cerebral aqueduct CSF dynamics by diffusion tensor imaging and its association with glymphatic function and cognitive decline in alzheimer’s spectrum

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By Lipeng Sun, Xinyuan Yang, Lin Kang, Yulei Deng, Wei Xu, Binyin Li, Xiaomeng Xu
| Nature Verified
Abstract Cerebrospinal fluid (CSF) plays a critical role in maintaining brain homeostasis through the clearance of neurotoxic metabolites, yet the relationship between CSF dynamics and cognitive dysfunction remains unclear. This study examined the diffusion metrics of CSF water molecules in the cerebral aqueduct and their association with cognitive impairment and Alzheimer’s disease (AD) pathology, aiming to establish a non-invasive neuroimaging marker of CSF diffusion properties.
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Advancing Alzheimer’s disease research in China: insights, innovations, and future directions from the chinese preclinical Alzheimer’s disease study (CPAS)

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By Jie Wang, Lin Huang, Binyin Li, Qihao Guo, Fang Xie
| Nature Verified
Abstract This review delves into the advancements in Alzheimer’s Disease (AD) research in China, focusing on insights, innovations, and future directions derived from the Chinese Preclinical Alzheimer’s Disease Study (CPAS). With an aging population, AD prevalence has risen, increasing societal and economic burdens. CPAS, initiated in 2019, aims to identify early Alzheimer’s pathology using plasma biomarkers and PET imaging.
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Regional juxtacortical microstructural changes and gene expression provide insights into neurodegeneration in Alzheimer’s disease

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By Junfang Zhang, Lipeng Sun, Xinyuan Yang, Lin Kang, Yingting Zheng, Qi Huang, Wei Xu, Yihui Guan, Jun Liu, Yulei Deng, Fang Xie, Xiaomeng Xu, Binyin Li
| Nature Verified
Abstract White matter microstructural changes play a crucial role in cognitive decline in aging and neurodegenerative disorders including Alzheimer’s disease (AD). However, the processes underlying white matter microstructural changes and the molecular pathways leading to these changes in AD remain largely unknown. AD involves cortical and juxtacortical microstructural changes, with free water fraction (FWF) as a potential imaging marker.
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