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Biologicals Laboratory

As seen in: Oxford University Press (OUP)
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Articles

Low level of Rituximab in human breast milk in a patient treated during lactation

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By Sanquin Diagnostic Services, Rheumatic Diseases, Biologicals Laboratory
| Oxford University Press (OUP)
Sir, Rituximab (RTX) is a chimeric mAb specifically targeting CD20 on B cells that induces the depletion of mature B cells and B cell precursors. The mean terminal elimination half-life in patients with vasculitis has been found to be 23 days (range: 9–49 days). In an animal study RTX was detected at low levels in breast milk of cynomolgus monkeys with concentrations of 0.19 and 0.26% of maternal serum level [1].
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