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Biomedical Simulations Resource

As seen in: Journal of Antimicrobial Chemotherapy
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Articles

Population-based meta-analysis of roxithromycin pharmacokinetics: dosing implications of saturable absorption and protein binding

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By Los Angeles, Michael J. Dolton, Biomedical Simulations Resource, David Z. D’Argenio
| Journal of Antimicrobial Chemotherapy Verified
Objectives: The macrolide antibiotic roxithromycin has seen widespread clinical use for several decades; however, no population pharmacokinetic analysis has been published. Early studies indicated saturation of protein binding and absorption at doses within the approved range, which may impact pharmacodynamic target attainment since regimens of 150?mg twice daily and 300?mg once daily are used interchangeably in clinical practice.
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