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Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability

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By Ning Li, Michael Makara, Mark Anderson Verified, Peter J. Mohler, Sathya D. Unudurthi, Xiangqiong Wu, Lan Qian, Foued Amari, Birce Onal, Sakima A. Smith, Jedidiah Snyder, Vadim V. Fedorov, Vincenzo Coppola
| jaha.ahajournals.org
Background Two‐pore K + channels have emerged as potential targets to selectively regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant animal models has impeded the effort to understand the role of 2‐pore K + channels in the heart and their potential as a therapeutic target. The objective of this study was to determine the role of mechanosensitive 2‐pore K + channel family member TREK‐1 in control of cardiac excitability.
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