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Birgitte S Wulff on Muck Rack

Birgitte S Wulff

As seen in: Color Research & Application, Wiley Online Library
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Articles

Long‐acting PYY3−36 analogue with semaglutide for obesity: from preclinical assessment through randomized clinical studies

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By Birgitte S Wulff, Adam Chambers, Katrine Kirkeby
| Wiley Online Library Verified
What is already known? The hormone peptide YY (PYY), particularly its Y2 receptor-selective form PYY3-36, is known to play a role in regulating hunger and satiety and has shown potential in reducing food intake and body weight in both animals and humans. There is significant interest in the combined use of PYY3-36 analogues and glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide, due to their synergistic effects on suppressing energy intake. What does this study add?
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The Design of a GLP‐1/PYY Dual Acting Agonist

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By Johan Paulsson, Marina Kjærgaard Gerstenberg, Birgitte S Wulff
| Color Research & Application Verified
Research Article In memory of Dr. Lauge Schäffer PDF ShareShare Abstract The two gut hormones GLP‐1 and PYY3–36, which are both secreted from the L‐cells upon food stimuli, have a stronger inhibitory effect on food intake when they are combined, compared to their individual effects as single agonists. Although they are not homologous and share no sequence similarity, we show that a GLP‐1 analogue can be designed to exhibit potent activity on both the Y2 and GLP‐1 receptors.
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