Birutė Grybaitė on Muck Rack

Birutė Grybaitė

As seen in: Wiley Online Library, MDPI, ACS Publications
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Articles

Identification and Characterization of a Small-Molecule Inhibitor of the Pseudomonas aeruginosa SOS Response

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By Filippo Vascon, Benedetta Fongaro, Antonella Pasquato, Birutė Grybaitė
| ACS Publications
Pseudomonas aeruginosa is an opportunistic bacterial pathogen of high clinical relevance, characterized by a broad spectrum of resistance to currently available antibiotics. (1) Finding new therapeutic strategies that efficiently and selectively kill this microorganism or increase its sensitivity to antibiotics is, thus, a priority.
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Synthesis and Characterization of Sulfonamide‐Imidazole Hybrids with In Vitro Antiproliferative Activity Against Anthracycline‐Sensitive and Resistant H69 SCLC Cells

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By Povilas Kavaliauskas, Birutė Grybaitė, Vidmantas Petraitis, Valdas Vainauskas
| Wiley Online Library Verified
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
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Identification and characterization of a small-molecule inhibitor of the Pseudomonas aeruginosa SOS response

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By Filippo Vascon, Benedetta Fongaro, Antonella Pasquato, Birutė Grybaitė
| biorxiv.org
Abstract The SOS response is among the most conserved pathways that promote the acquisition of antibiotic resistance in bacteria. This study aimed to identify and characterize small-molecule inhibitors of the SOS response system in the opportunistic pathogen Pseudomonas aeruginosa. A library of 318 drug-like compounds was screened for inhibition of RecA-induced LexA autoproteolysis, a key step in SOS activation.
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