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Fast ripple-delta DOWN state coupling detected at 4 days post-TBI distinguished seizure-prone from seizure-free mice. 25% of rdTBI mice developed posttraumatic seizures with highly variable latency ranging from 5 to 126 days postinjury. Spike activity increased 3-fold after seizure onset, yet preseizure spike counts alone did not predict PTE development. Elevated delta/theta and reduced alpha/beta/gamma power created consistent signatures in all seizure-experiencing mice.
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 Delay in diagnosis in a subset of patients. For each patient, the age of diagnosis was compared with the age when symptoms were first noted. Each point represents a patient. Points in orange indicate patients who had a gap of at least 1 year between first manifestation of symptoms and diagnosis.
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