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Articles

Genetic architecture of cytokine autoantibodies and associated risk of common diseases

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By Jakob Hjorth von Stemann, Joseph Dowsett, Rebecca Svanberg Teglgaard, Maria Didriksen, Frederikke Byron Pedersen, Mette Bentsen, Andrea Barghetti, Bente Glintborg, Ulrik Lassen, Ruth Frikke-Schmidt, Celeste Porsbjerg, Jens-Ulrik Stæhr Jensen, Thomas Werge, Andrew J. Schork, Johan Skov Bundgaard, Henning Bundgaard, Torben Frøstrup Hansen, Mie Topholm Bruun, Bitten Aagaard Jensen, Christina Mikkelsen, Christian Erikstrup, Ole Birger Pedersen, Erik S. Sørensen, Morten Hansen, Maria Vispe Laguarda, Hans-Jakob Hartling
| Nature Verified
Abstract Anti-cytokine autoantibodies are increasingly recognized as modulators of immune function and determinants of disease risk, yet their genetic basis and population-level impact remain unclear. Here we perform genome-wide association studies of autoantibodies against IL-1α, IL-6, IL-10, IFN-α, IFN-β, IFN-γ and GM-CSF in 15,000 individuals from the Danish Blood Donor Study. We identify 52 genome-wide significant loci, implicating genes enriched in antigen-presentation pathways.
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