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Kappa opioids suppress histaminergic itch by inhibiting mediodorsal thalamus-projecting claustrum glutamatergic neurons
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract Itch, an uncomfortable sensation that induces scratching, is suppressed by activation of kappa opioid receptors (KORs). KOR agonists, such as Nalfurafine, offer potent central antipruritic effects, yet the underlying mechanisms are not fully understood.
Incidence of community-acquired pneumonia among adults between 2016 and 2023: an observational cohort study | Epidemiology & Infection | Cambridge Core
Introduction Community-acquired pneumonia (CAP), a prevalent and life-threatening infectious disease, is associated with approximately 3 million deaths annually [1]. High mortality and recurrence rate in hospitalized CAP patients remains a substantial public health risk. In addition, mortality rates reaching up to 50% can be observed in patients with severe complications including sepsis, respiratory failure, and acute respiratory distress syndrome (ARDS) [Reference Schuetz2].
Green talent management as a driver of public sector well-being: insights from civil servants’ job satisfaction in China
1 Introduction As the backbone of society, providing essential services to the public, safeguarding the public interest, and promoting social equity and justice, the work of civil servants is vital to the development and stability of a country or region (Blijleven and Van Hulst, 2021; Neo et al., 2023; Van Der Steen et al., 2018).
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