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Blamey RW

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Articles

MYC regulation of glutamine-proline regulatory axis is key in luminal B breast cancer

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By Abd El-Rehim DM, Robertson JF, Blamey RW, Ellis IO
| Nature Verified
Altered cellular metabolism is a hallmark of cancer and some are reliant on glutamine for sustained proliferation and survival. We hypothesise that the glutamine–proline regulatory axis has a key role in breast cancer (BC) in the highly proliferative classes. Glutaminase (GLS), pyrroline-5-carboxylate synthetase (ALDH18A1), and pyrroline-5-carboxylate reductase 1 (PYCR1) were assessed at DNA/mRNA/protein levels in large, well-characterised cohorts.
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