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Bo Volf Brøchner on Muck Rack

Bo Volf Brøchner

As seen in: BioRxiv
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Articles

Single-vesicle tracking of α-synuclein oligomers reveals pore formation by a three-stage model modulated by charge, curvature, lipids and ligands

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By Mette Galsgaard Malle, Daniel Otzen, Xialin Zhang, Bo Volf Brøchner
| BioRxiv
Abstract Neurodegenerative disorders like Parkinson's disease (PD) pose significant health challenges. A major hallmark is the aggregation of α-synuclein into toxic oligomers (αSO) and fibrils. While many efforts focus on slowing disease progression, the molecular origins and mechanisms of αSO toxicity remain poorly understood, particularly its proposed link to membrane disruption.
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