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Bo-Yin Zhang on Muck Rack

Bo-Yin Zhang

As seen in: Nature, BioRxiv
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Articles

Targeting OTUD7A-HINT1 deubiquitination activates mTOR signaling for CNS regeneration

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By Zhen-Gang Liu, Ze-Yu Liu, Feng-Quan Zhou, Bo-Yin Zhang, Chang-Mei Liu, Yong-Quan Sun, Lai-Yang Zhou, Ling-Wei Zhao
| Nature Verified
Abstract Axon regeneration in the central nervous system (CNS) remains limited, imposing severe constraints on functional recovery after injury. Here, we reveal that the deubiquitinase OTU deubiquitinase 7 A (OTUD7A) critically regulates CNS regeneration by modulating histidine triad nucleotide-binding protein 1 (HINT1) stability. OTUD7A stabilizes HINT1 protein through specific removal of K63-linked ubiquitin chains at lysine 7.
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Exploring the mechanisms and potential therapeutic targets of Ferroptosis Related Genes in ankylosing spondylitis

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By Fan Yang, Zhen-Gang Liu, Peng-Fu Li, Bo-Yin Zhang
| BioRxiv
Abstract Background: Ferroptosis is a novel type of regulated cell death, and there is growing evidence that it is directly associated with the disease. Therefore, this study aimed to investigate the relevance of iron Ferroptosis-related genes to ankylosing spondylitis (AS) to propose a novel targeted therapy for AS patients. Methods: AS samples were downloaded from the Gene Expression Omnibus (GEO) database (GSE41038).
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