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Bo-Ying Bao on Muck Rack

Bo-Ying Bao

As seen in: Nature, PLOS ONE, MDPI, International Journal of Medical Sciences
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Articles

Lactic acid drives NLRP3 inflammasome activation and caspase-1–like cytokine cleavage via intracellular acidification

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By Hsin-An Lin, Hsin-Chung Lin, Yu-Jen Chen, Bo-Ying Bao, Jau-Song Yu, Kun-Yi Chien, Kuo-Yang Huang, David Ojcius, Lih-Chyang Chen, Ming-Hang Tsai, Kuen-Jou Tsai, Chieh-Tien Shih
| Nature Verified
Abstract Glycolysis is critical for NLRP3 inflammasome activation, yet the link between lactic acid metabolism and inflammasome signaling remains unclear. Here, we show that stimulation of macrophages with the NLRP3 activators nigericin or ATP induces lactic acid production and efflux via a lactate dehydrogenase–dependent pathway. Accumulation of intracellular lactic acid leads to cytoplasmic acidification, which promotes NLRP3 inflammasome activation.
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Unveiling DENND2D as a Novel Prognostic Biomarker for Prostate Cancer Recurrence: From Gene to Prognosis

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By Bo-Ying Bao
| MDPI
Open AccessArticle by Chi-Fen Chang 1, Lih-Chyang Chen 2, Yei-Tsung Chen 3, Chao-Yuan Huang 4, Chia-Cheng Yu 5,6,7, Victor C.
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Prognostic Significance of VAV3 Gene Variants and Expression in Renal Cell Carcinoma

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By Chi-Fen Chang, Bo-Ying Bao, Yu-Mei Hsueh, Pei-Ling Chen
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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