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Boao Xia

As seen in: Nature, BioRxiv
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Articles

Determinants that enable disordered protein assembly into discrete condensed phases - Nature Chemistry

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By Rachel M Welles, Kandarp A Sojitra, Mikael V. Garabedian, Boao Xia, Elizabeth Gallagher, Daniel A. Hammer, Jeetain Mittal
| Nature Verified
Abstract Cells harbour numerous mesoscale membraneless compartments that house specific biochemical processes and perform distinct cellular functions. These protein- and RNA-rich bodies are thought to form through multivalent interactions among proteins and nucleic acids, resulting in demixing via liquid–liquid phase separation. Proteins harbouring intrinsically disordered regions (IDRs) predominate in membraneless organelles.
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Engineered serum markers for non-invasive monitoring of gene expression in the brain - Nature Biotechnology

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By Sangsin Lee, Shirin Nouraein, Zhimin Huang, Boao Xia
| Nature Verified
Abstract Measurement of gene expression in the brain requires invasive analysis of brain tissue or non-invasive methods that are limited by low sensitivity. Here we introduce a method for non-invasive, multiplexed, site-specific monitoring of endogenous gene or transgene expression in the brain through engineered reporters called released markers of activity (RMAs). RMAs consist of an easily detectable reporter and a receptor-binding domain that enables transcytosis across the brain endothelium.
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Determinants of Disordered Protein Co-Assembly Into Discrete Condensed Phases

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By Mikael V. Garabedian, Rachel M Welles, Kandarp A Sojitra, Boao Xia
| BioRxiv
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