Bodour Salhia

Abstract Introduction: Variants of uncertain significance (VUS) on multigene cancer panels can increase patient anxiety and lead to unnecessary interventions. Prior literature shows that, compared to Non-Hispanic Whites, VUS are more frequent among other racial and ethnic groups due to underrepresentation in population genetics databases. However, self-reported race/ethnicity is an imperfect proxy for genetic ancestry.

Abstract Brain metastasis (BM) remains largely incurable. Cancer-associated fibroblasts (CAFs) can either support or inhibit tumor growth in the tumor microenvironment (TME), yet their role in BM is not well described. In this study we define four transcriptionally distinct CAF subpopulations using single-cell and spatial sequencing of human BM tissues.

In the current study, we studied patterns in authorship for publications related to cancer genomics research in Africa. The purpose was to use these data as a surrogate for a country's internal research capacity and to bring awareness to the dearth of knowledge in a field essential for understanding the cancer epidemic riddling the continent.